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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac threat elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, likely secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the proper coronary artery. Physicians and sufferers should be aware of the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
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- Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in men with established coronary artery disease .
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Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature
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Moreover, testosterone has been used in the treatment of lowered muscle mass and bone density in addition to anemia. The role testosterone could play within the growth of cardiovascular disease has more and more turn out to be the topic of present curiosity . Anabolic androgenic steroid use has elevated sex cams live over the previous decade, despite its potential for adverse results. They proceed for use by Olympic degree athletes, and have even spread to highschool degree athletes, noncompetitive bodybuilders and leisure athletes (Sullivan et al 1998; Dhar et al 2007).
Case Report
Unfortunately, the info on the use of excessive dose anabolic steroids in humans are mainly supplied as case reports or small studies that lack sufficient control groups. In addition, the info out there in the literature doesn’t account for the steroid kind or dose, as neither may be identified. Patients additionally could additionally be taking concomitant stimulants, corresponding to ephedra, which can confound data and the potential for adverse occasions. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 natural and synthetic derivatives of testosterone, might trigger a large spectrum of clinical sequalae.
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However, testosterone in physiologic doses might even be useful in patients with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in males with established coronary artery disease . Therefore, an interaction of endogenous elements of the patient’s danger profile in addition to the testosterone dosing may be problems with whether or not adverse occasions happen. Erythrocytosis has been reported as a possible impact of testosterone, which could be helpful in patients with anemia. The biggest threat of erythrocytosis happens with injectable forms of testosterone in contrast with transdermal preparations, especially in supraphysiologic doses. An improve of up to 44% of the baseline hematocrit has been reported .
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